Basic Information
VIS ID
TVIS44019076
Fusion event
HTLV-1-BDH1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q29
Reference genome
GRCh37/hg19
Start
197284535/197557664 (Hg38)
End
197284535/197557664 (Hg38)
Orient
-
Location type
Intronic
Target gene
BDH1
miRNAs that regulate target gene
hsa-mir-574-5p ; hsa-mir-6867-5p ; hsa-mir-3650 ; hsa-mir-4455 ; hsa-mir-6747-5p ; hsa-mir-589-3p ; hsa-mir-6782-5p ; hsa-mir-4773 ; hsa-mir-4666a-5p ; hsa-mir-493-5p ; hsa-mir-3177-5p ; hsa-mir-4735-3p ; hsa-mir-18b-5p ; hsa-mir-18a-5p ; hsa-mir-3660 ; hsa-mir-4526 ; hsa-mir-298
Nearest miRNA
hsa-let-7g/Upstream/263716; hsa-mir-922/Downstream/116832;
Nearest TSS
ENST00000440867/Upstream/1616; ENST00000608482/Downstream/15659;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/1407, chr3-CpG: 120/Downstream/69571
Upstream sequence
tgaaaccctgcccttcgtagtggatgcttgtaatcccagctaggtgggaggctgaggcagaagaattgcttaagcctgggaggcagaggttgcagtgagc
Downstream sequence
tgagatggtgccactgcattccagcctgggcaacagtgggagactgtctcaaaaaacaaacaaacaaataaaactgttggctctgtctgtccattctgtg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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