Basic Information
VIS ID
TVIS44019079
Fusion event
HTLV-1-ZNF385D integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p24.3
Reference genome
GRCh37/hg19
Start
21579840/21538348 (Hg38)
End
21579840/21538348 (Hg38)
Orient
-
Location type
Intronic
Target gene
ZNF385D
miRNAs that regulate target gene
hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-6868-3p ; hsa-mir-627-3p ; hsa-mir-6734-3p ; hsa-mir-3667-3p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-623 ; hsa-mir-2355-5p ; hsa-mir-3124-3p ; hsa-mir-5088-3p
Nearest miRNA
hsa-mir-12127/Upstream/1400707; hsa-let-7g/Downstream/4126525;
Nearest TSS
ENST00000440867/Upstream/27362; ENST00000412369/Downstream/4468;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/1351884, chr3-CpG: 86/Downstream/833653
Upstream sequence
gagttgagggagagaatcagctggagatacaaatatgggggtcatcTGGAAGTCTGTATTGATAACTTACTCCCTTCCCTCCATTTCCAGATACAGAAAC
Downstream sequence
ATTTCTTCTGTGAAGCAGAATTGGAAACCCTTTTGAGAGAATATATCTCTCTTCATGAGATAGGATAGGTTGTGTGATATGTTAACTTTCACTCTTTTAC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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