Basic Information
VIS ID
TVIS44019091
Fusion event
HTLV-1-LRRFIP2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p22.2
Reference genome
GRCh37/hg19
Start
37180107/37138616 (Hg38)
End
37180107/37138616 (Hg38)
Orient
-
Location type
Intronic
Target gene
LRRFIP2
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-3692-3p ; hsa-mir-6792-5p ; hsa-mir-922 ; hsa-mir-4719 ; hsa-mir-577 ; hsa-mir-3163 ; hsa-mir-15a-5p ; hsa-mir-6838-5p ; hsa-mir-497-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p
Nearest miRNA
hsa-mir-12127/Upstream/1394057; hsa-let-7g/Downstream/830788;
Nearest TSS
ENST00000440867/Upstream/26701; ENST00000607744/Downstream/35948;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/144751, chr3-CpG: 99/Downstream/36946
Upstream sequence
TTTCTTCAGGATGTAGGTACTTTAAGTATATagtagttcccccttatccaagtaagttccaagtccccccggagatgcctgaaactgcagatagtaccaa
Downstream sequence
accctatcccactgtcatcaatcagaacatgtttctgttcatgtcttccactcagaaatctagtcttttccatcataatatacttatcacacacactggc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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