Basic Information
VIS ID
TVIS44019094
Fusion event
HTLV-1-SCN10A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p22.2
Reference genome
GRCh37/hg19
Start
38762349/38720858 (Hg38)
End
38762349/38720858 (Hg38)
Orient
-
Location type
Intronic
Target gene
SCN10A
Nearest miRNA
hsa-mir-12127/Upstream/751378; hsa-let-7g/Downstream/417348;
Nearest TSS
ENST00000440867/Upstream/71185; ENST00000432250/Downstream/73152;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/70836, chr3-CpG: 57/Downstream/331120
Upstream sequence
AGAGAAGCAAAATGAGGAGAGAAGGCCCACAAGCCAATGACGTAGTGAGGAGAGCACCTGGCCAACAGCACATGTGGTTATTACTTTAATCCAGCAGGAC
Downstream sequence
TGGAAGGAGAAGAGCATAGGTGTGGAGAAAGCACTGCCCAGCCCTCTCTTGCCCCTGCAATTTGGCCTCTACACTGTGCTGAGGTCCGTGTGGACAATCA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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