Basic Information
VIS ID
TVIS44019100
Fusion event
HTLV-1-GASK1A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p22.1
Reference genome
GRCh37/hg19
Start
43046375/43004883 (Hg38)
End
43046375/43004883 (Hg38)
Orient
+
Location type
Intronic
Target gene
GASK1A
miRNAs that regulate target gene
hsa-mir-3162-5p ; hsa-mir-3941 ; hsa-mir-4756-5p ; hsa-mir-4739 ; hsa-mir-1321 ; hsa-mir-6760-5p ; hsa-mir-4789-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485
Nearest miRNA
hsa-mir-12127/Upstream/3866617; hsa-let-7g/Downstream/1109329;
Nearest TSS
ENST00000440867/Upstream/25335; ENST00000457115/Downstream/82596;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/25021, chr3-CpG: 20/Downstream/75046
Upstream sequence
Atgtattagcttcgtattggtgcggtaacaaattgctaggaacttgttggtttaaaacgacacgaattaattttcttacagttctggagactagaagtcc
Downstream sequence
aaagtgagtcttatttggctaaaatcaaggtgttggcagggccagttctttctggaggctctgggggagaatccatttccttgccacctctatcctttag
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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