Basic Information
VIS ID
TVIS44019129
Fusion event
HTLV-1-SYNPR integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p14.2
Reference genome
GRCh37/hg19
Start
63209204/63223528 (Hg38)
End
63209204/63223528 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA3B
Target gene
SYNPR
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-877-3p ; hsa-mir-877-5p ; hsa-mir-92a-3p ; hsa-mir-25-3p ; hsa-let-7a-5p
Nearest miRNA
hsa-let-7g/Upstream/2605658; hsa-mir-12124/Downstream/4001936;
Nearest TSS
ENST00000440867/Upstream/117553; ENST00000496889/Downstream/4787;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/348013, chr3-CpG: 20/Downstream/54785
Nearby gene
SYNPR(+54710) ;
Upstream sequence
CGTTTTTGAGTTTTCCACCTGATGAGACCTGGTGGGAGACGGGCTTGGTACCAGCTGAGACATCTCATGATTTGTGGCAGCCACAATGGTGTTCTTAACA
Downstream sequence
GACTATCGCCATGGTTTTAGCTAAGGTTCTGCCCCCCATTTTTTCCTGTCCattttgtcagccagccacgatcctttcaagaaattcctttttaaaacat
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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