Basic Information
VIS ID
TVIS44019132
Fusion event
HTLV-1-ATXN7 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p14.1
Reference genome
GRCh37/hg19
Start
63936046/63950370 (Hg38)
End
63936046/63950370 (Hg38)
Orient
-
Location type
Intronic
Target gene
ATXN7
miRNAs that regulate target gene
hsa-mir-192-5p ; hsa-mir-423-3p ; hsa-mir-342-3p ; hsa-mir-92a-3p ; hsa-mir-17-5p ; hsa-mir-3978 ; hsa-mir-4753-3p ; hsa-mir-452-3p ; hsa-mir-5093 ; hsa-mir-9-5p ; hsa-mir-130b-5p ; hsa-mir-4635 ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-6873-3p ; hsa-mir-519e-5p ; hsa-mir-515-5p ; hsa-mir-502-5p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-3124-3p ; hsa-mir-6845-3p ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-5695 ; hsa-mir-519d-5p ; hsa-mir-6832-3p ; hsa-mir-4262 ; hsa-mir-181d-5p ; hsa-mir-181c-5p ; hsa-mir-181b-5p ; hsa-mir-181a-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p
Nearest miRNA
hsa-let-7g/Upstream/3332500; hsa-mir-12124/Downstream/3275094;
Nearest TSS
ENST00000440867/Upstream/37782; ENST00000475897/Downstream/17374;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/37530, chr3-CpG: 55/Downstream/72837
Upstream sequence
GCTTTATTTTTAAAGGGGTAGAGGGTTAGTCCACAGAAGAATCTGGTATCTGGCAAAGTGATCTATTTTAAGCAACAGTGCTTTACATTCAGAACTGAGG
Downstream sequence
GAAATCACAGAGACCACCAGCAGCACATTGCAGAGACCTAAAACTAAACTAACACTGTTTATTTAATACTGTTTTAACTGCTATCTAATAATAAAACTAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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