Basic Information
VIS ID
TVIS44019151
Fusion event
HTLV-1-ROBO2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p12.3
Reference genome
GRCh37/hg19
Start
76229591/76180440 (Hg38)
End
76229591/76180440 (Hg38)
Orient
+
Location type
Intronic
Target gene
ROBO2
miRNAs that regulate target gene
hsa-mir-145-5p ; hsa-mir-342-5p ; hsa-mir-514b-3p ; hsa-mir-514a-3p ; hsa-mir-6844 ; hsa-mir-4801 ; hsa-mir-4731-3p ; hsa-mir-8084
Nearest miRNA
hsa-let-7g/Upstream/442077; hsa-mir-12124/Downstream/3327447;
Nearest TSS
ENST00000440867/Upstream/273638; ENST00000475034/Downstream/130656;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/273283, chr3-CpG: 63/Downstream/858907
Nearby gene
ZNF717(-394857) ;
Upstream sequence
ATCTGATTAAGTAGAAGcaggcacgtatccaactgcttaatttgatgacaccaaccaaaggagtctcacataaaatattgaaaagagaattcttcactca
Downstream sequence
ccccaaatttgtgcttcctgaatcttcaccatctaattaaatggtaccatcttccattttctcaagtagaaactttggtatctttgaagtctcacttttt
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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