Basic Information
VIS ID
TVIS44019173
Fusion event
HTLV-1-HTR1F integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p11.1
Reference genome
GRCh37/hg19
Start
87957425/87908275 (Hg38)
End
87957425/87908275 (Hg38)
Orient
-
Location type
Intronic
Target gene
HTR1F
miRNAs that regulate target gene
hsa-mir-6885-3p ; hsa-mir-3679-3p ; hsa-mir-6772-3p ; hsa-mir-1178-3p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-4268 ; hsa-mir-4448 ; hsa-mir-3934-3p ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-3667-3p ; hsa-mir-6734-3p ; hsa-mir-6832-3p ; hsa-mir-6887-3p ; hsa-mir-4518 ; hsa-mir-1266-5p ; hsa-mir-6823-5p
Nearest miRNA
hsa-let-7g/Upstream/681998; hsa-mir-12124/Downstream/8451689;
Nearest TSS
ENST00000440867/Upstream/114646; ENST00000319595/Downstream/82421;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/114862, chr3-CpG: 42/Downstream/150125
Nearby gene
HTR1F(+74301) ;
Upstream sequence
GTTGCCTTATATTACTATTAATCTATCATAAGAGATTCTGATACAGTGATACTTTATGTAGAACAGTTCAATAAATACCATGTAAGAAAACAAAAAGAAG
Downstream sequence
TAGATTGATATCACTTAAATTAAAAACCAGTGAATTTTCTATTTTGTGGAAAATAACCATATTGCTAAGTTATTATTATGAAATGTGTGTGCAGCTAGCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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