Basic Information
VIS ID
TVIS44019180
Fusion event
HTLV-1-PROS1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q11.1
Reference genome
GRCh37/hg19
Start
93688872/93970028 (Hg38)
End
93688872/93970028 (Hg38)
Orient
+
Location type
Intronic
Target gene
PROS1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-494-3p
Nearest miRNA
hsa-let-7g/Upstream/6743751; hsa-mir-12124/Downstream/2389936;
Nearest TSS
ENST00000440867/Upstream/11274; ENST00000478400/Downstream/3611;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/4855071, chr3-CpG: 39/Downstream/3682
Upstream sequence
CTATTGTTTCTTAGCACAGAATTAATAGTAAGAGAATGTGGCATAGGGTTTGATGTTGTATTACTGTATATTAGAAATTGTTTCTAACTCTTCCAGCACA
Downstream sequence
AACTCCAACTGTAACCTAACCTTGATAAAATCTCTCCATCAGTGCAACATTTTGGACTTTTTAGTAAAGATAATTTAAGAAAAGATAAGCCTTCATAACT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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