Basic Information
VIS ID
TVIS44019181
Fusion event
HTLV-1-ARL13B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q11.1
Reference genome
GRCh37/hg19
Start
93715679/93996835 (Hg38)
End
93715679/93996835 (Hg38)
Orient
+
Location type
Intronic
Target gene
ARL13B
miRNAs that regulate target gene
hsa-mir-106b-5p ; hsa-mir-132-3p ; hsa-mir-1266-3p ; hsa-mir-1277-5p ; hsa-mir-944 ; hsa-mir-5585-5p ; hsa-mir-548ax ; hsa-mir-548ao-5p ; hsa-mir-4502 ; hsa-mir-7849-3p ; hsa-mir-5692a ; hsa-mir-8054 ; hsa-mir-548k ; hsa-mir-548av-5p ; hsa-mir-559 ; hsa-mir-548y ; hsa-mir-548w ; hsa-mir-548o-5p ; hsa-mir-548j-5p ; hsa-mir-548i ; hsa-mir-548h-5p ; hsa-mir-548d-5p ; hsa-mir-548c-5p ; hsa-mir-548bb-5p ; hsa-mir-548b-5p ; hsa-mir-548ay-5p ; hsa-mir-548au-5p ; hsa-mir-548as-5p ; hsa-mir-548ar-5p ; hsa-mir-548aq-5p ; hsa-mir-548ap-5p ; hsa-mir-548am-5p ; hsa-mir-548ak ; hsa-mir-548ae-5p ; hsa-mir-548ad-5p ; hsa-mir-548ab ; hsa-mir-548a-5p ; hsa-mir-3149 ; hsa-mir-568 ; hsa-mir-8068 ; hsa-mir-6516-3p ; hsa-mir-1206 ; hsa-mir-5000-5p
Nearest miRNA
hsa-let-7g/Upstream/6770558; hsa-mir-12124/Downstream/2363129;
Nearest TSS
ENST00000440867/Upstream/16547; ENST00000477077/Downstream/31775;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/16246, chr3-CpG: 36/Downstream/65969
Upstream sequence
GACTTTGTTGGGCACCTAGAATGTATCACCAGTCAGGCATCTAAAGTgagtccccaaccccggggccgtggaccaatatctgtctgtgggctggttctta
Downstream sequence
ggaaccagcccacaaagcaggaggtaagcagcaggccagtgaacgaagcttcatctgtatttacatcctctccccattactcacattactgcctgaacat
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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