Basic Information
VIS ID
TVIS44019210
Fusion event
HTLV-1-ALPK1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q25
Reference genome
GRCh37/hg19
Start
113231439/112310283 (Hg38)
End
113231439/112310283 (Hg38)
Orient
+
Location type
Intronic
Target gene
ALPK1
Nearest miRNA
hsa-mir-12113/Upstream/1449636; hsa-mir-1243/Downstream/337591;
Nearest TSS
ENST00000502981/Upstream/12882; ENST00000505912/Downstream/72221;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/24161, chr4-CpG: 24/Downstream/69113
Upstream sequence
GCTCACAAGTGAAATTTTCCCCATGGGTTAAATTGAAAAATTAATTCATAAATTCATCAACATAACACTTGGAGAACTGCATCTATTTTCTTATAAGTAT
Downstream sequence
ATAATAACACCTACTCAACTAGAGATGGTAGAAGGTTGTAACATTTGAGAGGCTCCAGATCCTTCCAGATGCCTCCTTTGATTTGGTGTTGCATAACAAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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