Basic Information
VIS ID
TVIS44019231
Fusion event
HTLV-1-UVSSA integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p16.3
Reference genome
GRCh37/hg19
Start
1343425/1349637 (Hg38)
End
1343425/1349637 (Hg38)
Orient
-
Location type
Exonic
Target gene
UVSSA
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-15b-5p
Nearest miRNA
hsa-mir-571/Upstream/999385; hsa-mir-12113/Downstream/636747;
Nearest TSS
ENST00000502981/Upstream/1931; ENST00000505716/Downstream/4870;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/1954, chr4-CpG: 16/Downstream/20721
Upstream sequence
AGCTGAGCCGCGCCTACCGCCTGCTGATAGCACAGCTGACCCAGGAGCACGCCGAGATCCGTCTCTCAGCCTTCCAGATTGTGGAGGAACTCTTCGTCAG
Downstream sequence
GTCTCACCAGTTCCGGATGCTGGTTGTTTCCAACTTCCAGGAGTTCCTGGAGCTCACGCTGGGCACAGACCCCGCACAGCCTCTGCCGCCCCCCAGGGAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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