Basic Information
VIS ID
TVIS44019238
Fusion event
HTLV-1-GAB1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q31.21
Reference genome
GRCh37/hg19
Start
144326673/143405520 (Hg38)
End
144326673/143405520 (Hg38)
Orient
-
Location type
Intronic
Target gene
GAB1
miRNAs that regulate target gene
hsa-mir-17-5p ; hsa-mir-181d-5p ; hsa-mir-20a-5p ; hsa-mir-93-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p ; hsa-mir-30a-5p ; hsa-mir-30c-5p ; hsa-mir-30d-5p ; hsa-mir-30b-5p ; hsa-mir-30e-5p ; hsa-mir-409-3p
Nearest miRNA
hsa-mir-12113/Upstream/61985; hsa-mir-1305/Downstream/3003063;
Nearest TSS
ENST00000502981/Upstream/14010; ENST00000511836/Downstream/9989;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/67586, chr4-CpG: 107/Downstream/107576
Upstream sequence
TTTTGTTCACTGAGCCTTGTGGGCTGGAGATTTGAGAGTTTATGGCTGAATTCTTACAACAATAAGAAAACCCACTATTGGTTTGTTGTATCATCCATTA
Downstream sequence
TACCTGAAGGCCAAGTTAGTGAAGAACAGAGACAGCATCATTACCAAATGAATTAAGACATTCATTCATTTGTTCATTTATTCAGGCAACAGTTATCACC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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