Basic Information
VIS ID
TVIS44019248
Fusion event
HTLV-1-LRBA integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
151558862/150637710 (Hg38)
End
151558862/150637710 (Hg38)
Orient
-
Location type
Intronic
Target gene
LRBA
miRNAs that regulate target gene
hsa-mir-1229-3p ; hsa-mir-93-3p ; hsa-mir-769-5p ; hsa-mir-615-3p
Nearest miRNA
hsa-mir-12113/Upstream/2855042; hsa-mir-1305/Downstream/1851617;
Nearest TSS
ENST00000502981/Upstream/55788; ENST00000503002/Downstream/41957;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/53777, chr4-CpG: 89/Downstream/377791
Upstream sequence
gtaagccaccatactggagaagtccctgtggcaaagaactcagggccttagtccaagagccctcaaaggattaaattctgacaacttcataagtgaactt
Downstream sequence
gaaagtggatacttcccagttgagccttcagatgagaacccagcctgcggacaccttgactaaagccatatcagagatggtgggccagaggaaacagcta
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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