Basic Information
VIS ID
TVIS44019249
Fusion event
HTLV-1-ARFIP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
153762573/152841421 (Hg38)
End
153762573/152841421 (Hg38)
Orient
+
Location type
Intronic
Target gene
ARFIP1
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-124-3p ; hsa-mir-23b-3p ; hsa-mir-877-3p
Nearest miRNA
hsa-mir-12113/Upstream/304905; hsa-mir-1305/Downstream/6287381;
Nearest TSS
ENST00000502981/Upstream/61312; ENST00000513361/Downstream/9222;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/61082, chr4-CpG: 232/Downstream/94539
Upstream sequence
ccgtgccaggccagttctgtatcttttaagtagagcatttagaccatttgtattcaatgttagtattgaaatgtgaggtacggttgcattcattgtgctc
Downstream sequence
tttgttgcctgtgtacttttgttttttgtttttgctttttaatgtgtatttttgttttataggacctgtatgatttatgctttaaagaggttctgttttg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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