Basic Information
VIS ID
TVIS44019251
Fusion event
HTLV-1-TRIM2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
154168209/153247057 (Hg38)
End
154168209/153247057 (Hg38)
Orient
-
Location type
Intronic
Target gene
TRIM2
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-181c-5p ; hsa-mir-335-5p ; hsa-mir-130b-3p ; hsa-mir-181a-5p ; hsa-mir-10a-5p ; hsa-mir-21-5p ; hsa-mir-19b-3p ; hsa-mir-186-5p ; hsa-mir-10b-5p ; hsa-mir-3190-3p ; hsa-mir-493-5p ; hsa-mir-574-5p ; hsa-mir-1277-5p ; hsa-mir-190a-3p ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-5690 ; hsa-mir-511-3p ; hsa-mir-5011-5p ; hsa-mir-374b-5p ; hsa-mir-374a-5p ; hsa-mir-655-3p ; hsa-mir-374c-5p ; hsa-mir-410-3p ; hsa-mir-5692c ; hsa-mir-5692b ; hsa-mir-369-3p ; hsa-mir-6079 ; hsa-mir-411-5p ; hsa-mir-3117-3p ; hsa-mir-1258 ; hsa-mir-671-5p ; hsa-mir-6828-5p ; hsa-mir-3681-5p ; hsa-mir-6849-5p ; hsa-mir-1244 ; hsa-mir-1197 ; hsa-mir-504-5p
Nearest miRNA
hsa-mir-12113/Upstream/710541; hsa-mir-1305/Downstream/5881745;
Nearest TSS
ENST00000502981/Upstream/24112; ENST00000502281/Downstream/10322;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/23746, chr4-CpG: 22/Downstream/2159
Upstream sequence
AGAGTGCATTCATTTGGAGGAGGATGTGGAAGTGAGGCCTCCCGTTCTCATGTCCAGAGACGATGACTTACATCAAAGGGCAAAACTGACGCTGGAAGGG
Downstream sequence
GACCAAAAGGAATCATTTCTCTTCTGATCTTTTTAAGAAGGCTGCTGGCTCTAAGGGAGAGATGCTGGCCACTGAGGACTCATTTCCACAGGCCGCTGAC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate