Basic Information
VIS ID
TVIS44019286
Fusion event
HTLV-1-PALLD integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q32.3
Reference genome
GRCh37/hg19
Start
169553491/168632340 (Hg38)
End
169553491/168632340 (Hg38)
Orient
+
Location type
Intronic
Target gene
PALLD
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-124-3p ; hsa-mir-21-5p ; hsa-mir-19b-3p ; hsa-mir-196a-5p ; hsa-mir-218-5p ; hsa-mir-6869-5p ; hsa-mir-610 ; hsa-mir-4717-5p ; hsa-mir-6856-5p ; hsa-mir-6758-5p ; hsa-mir-33b-5p ; hsa-mir-33a-5p ; hsa-mir-4279 ; hsa-mir-6749-3p ; hsa-mir-1298-5p ; hsa-mir-656-5p ; hsa-mir-3667-3p ; hsa-mir-6734-3p ; hsa-mir-3162-3p ; hsa-mir-1250-3p ; hsa-mir-483-3p ; hsa-mir-4775 ; hsa-mir-4694-5p
Nearest miRNA
hsa-mir-12113/Upstream/3246003; hsa-mir-1305/Downstream/2553844;
Nearest TSS
ENST00000502981/Upstream/723; ENST00000513245/Downstream/16247;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/544, chr4-CpG: 117/Downstream/199557
Upstream sequence
TGTTTAACTTGCCTGCTGCGATTTGAGCCCAATGAGTTTGTATTTTCTCTAATTACTTTGTAATCGGCTCCATCCTCGGTTGAAATAGAAGGAAACTTTC
Downstream sequence
ACAAAGCAATCAATTTCTGACAGCCTAAGAGCTGCTCAGTTGCTGAATGAGGTCTAGCTGGAAACACTTTGTTTCTCACAAGGTTTTGGTGATTTTTCCC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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