Basic Information
VIS ID
TVIS44019292
Fusion event
HTLV-1-GALNT7 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q34.1
Reference genome
GRCh37/hg19
Start
174240313/173319162 (Hg38)
End
174240313/173319162 (Hg38)
Orient
-
Location type
Intronic
Target gene
GALNT7
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-30a-5p ; hsa-mir-378a-3p ; hsa-mir-214-3p ; hsa-mir-374b-5p ; hsa-mir-124-3p ; hsa-mir-26b-5p ; hsa-mir-17-3p ; hsa-mir-154-5p ; hsa-mir-125b-2-3p ; hsa-mir-4731-3p ; hsa-mir-4801 ; hsa-mir-25-3p ; hsa-mir-32-5p ; hsa-mir-92a-3p ; hsa-mir-363-3p ; hsa-mir-367-3p ; hsa-mir-92b-3p ; hsa-mir-660-5p ; hsa-mir-548k ; hsa-mir-4282 ; hsa-mir-3973 ; hsa-mir-219b-3p ; hsa-mir-5591-3p ; hsa-mir-548av-5p ; hsa-mir-8054 ; hsa-mir-5700 ; hsa-mir-34c-5p ; hsa-mir-34b-3p ; hsa-mir-34a-5p ; hsa-mir-552-5p ; hsa-mir-4666a-5p ; hsa-mir-374a-5p ; hsa-mir-8064
Nearest miRNA
hsa-mir-12113/Upstream/50929; hsa-mir-1305/Downstream/1104633;
Nearest TSS
ENST00000502981/Upstream/3321; ENST00000504618/Downstream/10532;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/148890, chr4-CpG: 158/Downstream/14370
Upstream sequence
ATGTAGCTAGTTGCTTACTTTAATGGTCAAATTTAGTTATTCACGTGACACTGCTGGGGTAGCTTTGTGTTTCAGCTGTGAGTATTTAAAGCTCTGTGGC
Downstream sequence
AAGTTGAGGATTACAACATATTAATAGATTTATGTATAGTTTTCAAATTCTAGATTTGGCTAACATAAATCAATTTATTATTAAACAAAAAGTGGGGAAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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