Basic Information
VIS ID
TVIS44019296
Fusion event
HTLV-1-NCAPG integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p15.31
Reference genome
GRCh37/hg19
Start
17829578/17827955 (Hg38)
End
17829578/17827955 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA4D
Target gene
NCAPG
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-193b-3p ; hsa-mir-155-5p ; hsa-mir-1-3p ; hsa-mir-34a-5p ; hsa-mir-16-5p ; hsa-mir-421 ; hsa-mir-575 ; hsa-mir-6868-3p ; hsa-mir-664b-3p ; hsa-mir-579-3p ; hsa-mir-5696 ; hsa-mir-4536-5p ; hsa-mir-205-5p ; hsa-mir-153-5p ; hsa-mir-1250-3p ; hsa-mir-181d-5p ; hsa-mir-181b-5p ; hsa-mir-181c-5p ; hsa-mir-181a-5p
Nearest miRNA
hsa-mir-12113/Upstream/4199998; hsa-mir-12115/Downstream/2700320;
Nearest TSS
ENST00000502981/Upstream/4256; ENST00000511431/Downstream/134077;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/16351, chr4-CpG: 178/Downstream/192857
Upstream sequence
agtgcagtggcatgatctcagctcactgcaacctccacctcccgtgttcaagccattctcgtgcctcggcctcccaagtagctgggaccacaggtgtgca
Downstream sequence
ccaccacactaatttttgtgtttttagtagagatgaagttttgccatgttgaccaggctggtcctaaattcctgaccttaagtgatttacctgccttggc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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