Basic Information
VIS ID
TVIS44019302
Fusion event
HTLV-1-WWC2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q35.1
Reference genome
GRCh37/hg19
Start
184039377/183118224 (Hg38)
End
184039377/183118224 (Hg38)
Orient
+
Location type
Intronic
Target gene
WWC2
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-21-5p ; hsa-mir-5584-3p ; hsa-mir-7850-5p ; hsa-mir-5004-3p ; hsa-mir-3658 ; hsa-mir-499a-5p ; hsa-mir-208b-3p ; hsa-mir-208a-3p ; hsa-mir-641 ; hsa-mir-3617-5p ; hsa-mir-3152-5p ; hsa-mir-4774-3p ; hsa-mir-6836-3p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-623 ; hsa-mir-664b-3p ; hsa-mir-6829-3p ; hsa-mir-6791-3p ; hsa-mir-6778-3p ; hsa-mir-150-5p ; hsa-mir-3121-5p ; hsa-mir-6832-3p ; hsa-mir-4699-3p ; hsa-mir-8485 ; hsa-mir-561-5p ; hsa-mir-615-5p ; hsa-mir-3936 ; hsa-mir-7156-3p ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-3944-5p ; hsa-mir-766-3p ; hsa-mir-6849-3p ; hsa-mir-4691-3p ; hsa-mir-596
Nearest miRNA
hsa-mir-12113/Upstream/948846; hsa-mir-3945/Downstream/1732789;
Nearest TSS
ENST00000502981/Upstream/18732; ENST00000506225/Downstream/75391;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/17998, chr4-CpG: 57/Downstream/280187
Upstream sequence
TCTTATAGTCGAGCCTCAGTCTTAGAGGAAAAATAGTTTCTTTCAGTCGATTGCCACGTTATAGTTTGCTTTAAACTACTTAGATTTGGATTCAGGGTAA
Downstream sequence
AGAGCCTTCATAAATAGGAAGTGATAGAAATTCAGAGGGAGTGTGGCATGTTTTTGTTGGATTTACTTATGCTGTGAAACTTACCTAGAAGTGTACAGGC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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