Basic Information
VIS ID
TVIS44019305
Fusion event
HTLV-1-CASP3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q35.1
Reference genome
GRCh37/hg19
Start
185550501/184629347 (Hg38)
End
185550501/184629347 (Hg38)
Orient
-
Location type
Exonic
Target gene
CASP3
miRNAs that regulate target gene
hsa-mir-98-5p ; hsa-let-7a-5p ; hsa-mir-30d-5p ; hsa-mir-138-5p ; hsa-mir-375 ; hsa-mir-128-3p ; hsa-mir-221-3p ; hsa-mir-26b-5p ; hsa-mir-196a-5p ; hsa-mir-421 ; hsa-let-7g-5p ; hsa-mir-651-3p ; hsa-mir-6124 ; hsa-let-7b-3p ; hsa-mir-30c-5p ; hsa-mir-582-5p ; hsa-mir-363-3p ; hsa-mir-885-5p ; hsa-mir-374a-5p ; hsa-mir-382-5p ; hsa-mir-3680-3p ; hsa-mir-4666b ; hsa-mir-5011-3p ; hsa-mir-6797-3p ; hsa-mir-6076 ; hsa-mir-888-5p ; hsa-mir-562 ; hsa-mir-548n ; hsa-mir-30e-5p ; hsa-mir-30a-5p ; hsa-mir-30b-5p ; hsa-mir-224-5p ; hsa-mir-26a-1-3p ; hsa-mir-34a-5p ; hsa-mir-155-5p ; hsa-let-7c-5p
Nearest miRNA
hsa-mir-12113/Upstream/2459969; hsa-mir-3945/Downstream/221666;
Nearest TSS
ENST00000502981/Upstream/4317; ENST00000509538/Downstream/19245;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/154320, chr4-CpG: 110/Downstream/19460
Upstream sequence
AAAAACCACCAACCAACCATTTCTTTAGTGATAAAAATAGAGTTCTTTTGTGAGCATGGAAACAATACATGGAATCTGTTTCTTTGCATGAAAAGTAGCG
Downstream sequence
TCAAAGGAAAAGGACTCAAATTCTGTTGCCACCTTTCGGTTAACCCGGGTAAGAATGTGCATAAATTCAAGCTTGTCGGCATACTGTTTCAGCATGGCAC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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