Basic Information
VIS ID
TVIS44019318
Fusion event
HTLV-1-POLN integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p16.3
Reference genome
GRCh37/hg19
Start
2109508/2107781 (Hg38)
End
2109508/2107781 (Hg38)
Orient
-
Location type
Intronic
Target gene
POLN
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-571/Upstream/121304; hsa-mir-12113/Downstream/142296;
Nearest TSS
ENST00000502981/Upstream/17476; ENST00000502636/Downstream/31892;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/43110, chr4-CpG: 71/Downstream/133743
Upstream sequence
tgaggtaggagagaggaagaggggaggcaggactgCTGCCTGCAGGTACTGGCCATGGCACTGAGCTCCCTCCAgacccactgagtttgaaatgcttgtg
Downstream sequence
ggacagccagggaaaactgccgctggggcctggaatgcttgcctgaggtcaggacagagAGGAGCTACAATGACCATAACAGCCACATATTGCCAATGAT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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