Basic Information
VIS ID
TVIS44019324
Fusion event
HTLV-1-ZFYVE28 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p16.3
Reference genome
GRCh37/hg19
Start
2276994/2275267 (Hg38)
End
2276994/2275267 (Hg38)
Orient
+
Location type
Intronic
Target gene
ZFYVE28
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-192-5p
Nearest miRNA
hsa-mir-4800/Upstream/25111; hsa-mir-12113/Downstream/3648008;
Nearest TSS
ENST00000502981/Upstream/3516; ENST00000510632/Downstream/12448;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/12325, chr4-CpG: 30/Downstream/525
Upstream sequence
AGGCTGAGGGACCCTCCGTGCATGGGGTCTCCATCTTCCCAGCAGCTGCGTCCTCAGCTTTCATCAGATTTGCTACTCAGGGGTTCCACGGTGACCCTAT
Downstream sequence
AAATCGTTCACAGCTGGGCCTGTACTAACTCCGGAGGTTCACCTCGCCCAACTCTAGGGGTGCACCCACTGGCCCTCTCATTTTAAActaatttatctcc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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