Basic Information
VIS ID
TVIS44019350
Fusion event
HTLV-1-RBM47 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p14
Reference genome
GRCh37/hg19
Start
40454042/40452025 (Hg38)
End
40454042/40452025 (Hg38)
Orient
+
Location type
Intronic
Target gene
RBM47
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-124-3p ; hsa-mir-335-5p ; hsa-mir-3658 ; hsa-mir-516b-5p ; hsa-mir-3191-5p ; hsa-mir-3653-3p ; hsa-mir-504-3p ; hsa-mir-298 ; hsa-mir-4670-3p ; hsa-mir-6824-3p ; hsa-mir-6764-3p ; hsa-mir-330-5p ; hsa-mir-326 ; hsa-mir-518c-5p ; hsa-mir-216b-5p ; hsa-mir-122-5p ; hsa-mir-627-3p ; hsa-mir-153-5p ; hsa-mir-1250-3p ; hsa-mir-382-3p ; hsa-mir-129-5p ; hsa-mir-3680-3p ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-450b-5p ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-6881-3p ; hsa-mir-6780a-3p ; hsa-mir-7111-3p ; hsa-mir-4778-3p ; hsa-mir-877-3p
Nearest miRNA
hsa-mir-12113/Upstream/1040051; hsa-mir-1243/Downstream/50015;
Nearest TSS
ENST00000502981/Upstream/25906; ENST00000473399/Downstream/14620;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/13137, chr4-CpG: 66/Downstream/177698
Upstream sequence
ttgggaggccaaggcgggcagattgcctgaggtcaggagttcgagaccagcctggccaacatggcaaaaccctgtctctactaaaaatacaaaaattagc
Downstream sequence
cgggtgtggtggcatgtgcctgtagtctcagctacttgggagggtgaggcaggagaattgcttgaacccaggaggtagaggctgcaatgagccgagatca
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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