Basic Information
VIS ID
TVIS44019356
Fusion event
HTLV-1-GABRA2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p12
Reference genome
GRCh37/hg19
Start
46322898/46320881 (Hg38)
End
46322898/46320881 (Hg38)
Orient
-
Location type
Intronic
Target gene
GABRA2
miRNAs that regulate target gene
hsa-mir-30e-3p ; hsa-mir-30d-3p ; hsa-mir-30a-3p ; hsa-mir-222-5p ; hsa-mir-545-5p ; hsa-mir-205-3p
Nearest miRNA
hsa-mir-12113/Upstream/5818762; hsa-mir-1243/Downstream/1331788;
Nearest TSS
ENST00000502981/Upstream/15304; ENST00000502455/Downstream/67832;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/1594179, chr4-CpG: 65/Downstream/69005
Upstream sequence
atgtacactgttggtggggatgtaaattggtgtatccattagggaaaacaatattgatattcctcaaaatgttaaaagcagaatctttctgttaggtata
Downstream sequence
tacccaagagaaatgaaatcatgacctttaaagatattggcattcacatgctcattgtagcattattcacaatacccaatatacaaaaacaatctaagtg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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