Basic Information
VIS ID
TVIS44019398
Fusion event
HTLV-1-ANKRD17 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
74007487/73141770 (Hg38)
End
74007487/73141770 (Hg38)
Orient
+
Location type
Exonic
Target gene
ANKRD17
miRNAs that regulate target gene
hsa-mir-23b-3p ; hsa-mir-1-3p ; hsa-mir-16-5p ; hsa-mir-424-5p ; hsa-mir-186-5p ; hsa-let-7c-5p ; hsa-let-7b-5p ; hsa-let-7a-5p ; hsa-mir-664b-3p ; hsa-mir-579-3p ; hsa-mir-549a ; hsa-mir-4699-3p ; hsa-mir-582-5p ; hsa-mir-101-3p ; hsa-mir-885-5p ; hsa-mir-6504-3p
Nearest miRNA
hsa-mir-12113/Upstream/6864842; hsa-mir-1243/Downstream/3431798;
Nearest TSS
ENST00000502981/Upstream/37690; ENST00000502790/Downstream/12165;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/71837, chr4-CpG: 62/Downstream/116918
Upstream sequence
GTCTATTTTTTGGTAATCTTATTTTTACCTGGACACCAAGTAAGAAACAGTCTTTAGAAGTATAACTGACCTTTATTCCTGATGGGAAGAGTGGTGGCAA
Downstream sequence
CATTGGCAGGTGGTTTGTCAGGCTCCTGAGGTGGAACAACCATGGGCAGTGCTTGAACTGGTACACGAGGAGCCTAAGACAAAGGACACTAAGTGACTAT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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