Basic Information
VIS ID
TVIS44019408
Fusion event
HTLV-1-BMP2K integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q21.21
Reference genome
GRCh37/hg19
Start
79701717/78780563 (Hg38)
End
79701717/78780563 (Hg38)
Orient
+
Location type
Intronic
Target gene
BMP2K
miRNAs that regulate target gene
hsa-mir-192-5p ; hsa-mir-98-5p ; hsa-let-7e-5p ; hsa-mir-1228-3p ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-1277-5p ; hsa-mir-6885-3p ; hsa-mir-6771-3p ; hsa-mir-1909-5p ; hsa-mir-4693-3p ; hsa-mir-551b-5p ; hsa-mir-4311 ; hsa-mir-548c-3p ; hsa-mir-4477a ; hsa-mir-508-5p ; hsa-mir-3145-5p ; hsa-mir-606 ; hsa-mir-5582-3p ; hsa-mir-548f-3p ; hsa-mir-548e-3p ; hsa-mir-548az-3p ; hsa-mir-548ar-3p ; hsa-mir-548a-3p ; hsa-mir-4672 ; hsa-mir-466 ; hsa-mir-3941 ; hsa-mir-610 ; hsa-mir-4643 ; hsa-mir-4789-3p ; hsa-mir-4465 ; hsa-mir-26b-5p ; hsa-mir-26a-5p ; hsa-mir-1297 ; hsa-mir-5697 ; hsa-mir-101-5p ; hsa-mir-8062 ; hsa-mir-8079 ; hsa-mir-1245a
Nearest miRNA
hsa-mir-12113/Upstream/2204937; hsa-mir-1243/Downstream/3972774;
Nearest TSS
ENST00000502981/Upstream/4185; ENST00000515075/Downstream/70329;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/3759, chr4-CpG: 68/Downstream/158496
Upstream sequence
TCTCGTTGTTAATTTTTCAGGAAGGTTGTACTATACATCTGATTTTGCACTATAAATTAGTAGGGAAATGATAGATTTAAGCATTATATCTCATTTGCAG
Downstream sequence
AAAGCATCTGTGGCTGCCCAGTAACTTGTAAGTTCACATTCCGAAGAGAAGATAGAGAGGATAGAAAAAAGGGAAGGATCGAATAAAAATATCAACAACT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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