Basic Information
VIS ID
TVIS44019409
Fusion event
HTLV-1-AFAP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p16.1
Reference genome
GRCh37/hg19
Start
7897584/7895857 (Hg38)
End
7897584/7895857 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA4A
Target gene
AFAP1
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-26b-5p ; hsa-mir-3613-5p ; hsa-mir-2115-5p ; hsa-mir-646 ; hsa-mir-1185-2-3p ; hsa-mir-1185-1-3p ; hsa-let-7f-2-3p ; hsa-mir-4789-5p ; hsa-mir-98-3p ; hsa-let-7f-1-3p ; hsa-let-7b-3p ; hsa-let-7a-3p ; hsa-mir-942-3p ; hsa-mir-5582-3p ; hsa-mir-4802-3p ; hsa-mir-548f-3p ; hsa-mir-548e-3p ; hsa-mir-548az-3p ; hsa-mir-548ar-3p ; hsa-mir-548a-3p ; hsa-mir-578
Nearest miRNA
hsa-mir-378d-1/Upstream/435739; hsa-mir-12113/Downstream/109444;
Nearest TSS
ENST00000502981/Upstream/23544; ENST00000623059/Downstream/43144;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/95144, chr4-CpG: 156/Downstream/42979
Upstream sequence
GGAATTAGCAGCTCAGTGATCTTTGCTTCAAAAAAGCAAAAAGACCACATTCACACTTTACCACTTCTACATGGAAGTGTGTGTTCTTCAGAAAGttttt
Downstream sequence
ttttttttttttttttttaagacgggagtttcactcttatgcccaggctggagtgcagtggcgcgatcttggctcaccacaacctctgtgcctcccacgt
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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