Basic Information
VIS ID
TVIS44019420
Fusion event
HTLV-1-PTPN13 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
87549605/86628452 (Hg38)
End
87549605/86628452 (Hg38)
Orient
+
Location type
Intronic
Target gene
PTPN13
miRNAs that regulate target gene
hsa-mir-200c-3p ; hsa-mir-194-5p ; hsa-mir-331-3p ; hsa-mir-186-5p ; hsa-mir-92a-3p ; hsa-mir-26a-5p
Nearest miRNA
hsa-mir-12113/Upstream/85900; hsa-mir-1243/Downstream/672043;
Nearest TSS
ENST00000502981/Upstream/32759; ENST00000508063/Downstream/6800;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/33633, chr4-CpG: 72/Downstream/263567
Nearest cancer related gene
PTPN13(TSG, No orient, 0)
Upstream sequence
ttgccagccgtatatcttctctgatgtccattcaaatctaaaaaaaactggattgtttggttttttaattatatattctggatataagtcctttatcagt
Downstream sequence
tatatgatttgcagtatttttccttagtttgtggttcattttttTTTTTAAtttttttttttattatactctaagttttagggtacatgtgcacattgtg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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