VISDB Viral Integration Site DataBase

VIS ID

TVIS44019421

Fusion event

HTLV-1-AFF1 integration

Validated

No

Detection method

HTS

Data source

download(RID)

Sample type

Disease

HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)

Quality evaluation

Normal

Reported year

2017

PubMed ID

Virus name

HTLV-1

Reference genome

Not given

Chromosome

chr4

Cytoband

q21.3

Reference genome

Start

End

87976646/87055494 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-128b ; hsa-mir-877-5p ; hsa-mir-615-3p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-142-3p ; hsa-mir-6073 ; hsa-mir-1914-5p ; hsa-mir-587 ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-93-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p ; hsa-mir-885-3p ; hsa-mir-5197-5p ; hsa-mir-205-5p ; hsa-mir-1228-3p ; hsa-mir-519e-3p ; hsa-mir-515-3p ; hsa-mir-33b-3p ; hsa-mir-371a-3p ; hsa-mir-371b-3p ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-4279 ; hsa-mir-361-5p ; hsa-mir-889-3p ; hsa-mir-660-3p ; hsa-mir-5193 ; hsa-mir-1324 ; hsa-mir-2115-3p ; hsa-mir-3074-3p ; hsa-mir-5571-5p ; hsa-mir-7161-5p ; hsa-mir-548u ; hsa-mir-4744 ; hsa-mir-1273h-3p ; hsa-mir-143-5p ; hsa-mir-3944-5p ; hsa-mir-5093 ; hsa-mir-4480 ; hsa-mir-3166 ; hsa-mir-4771 ; hsa-mir-6790-3p ; hsa-mir-3691-3p ; hsa-mir-548an ; hsa-mir-31-5p ; hsa-mir-5684 ; hsa-mir-4511 ; hsa-mir-548b-3p ; hsa-mir-5692b ; hsa-mir-5692c

Nearest miRNA

hsa-mir-12113/Upstream/512942; hsa-mir-1243/Downstream/245001;

Nearest TSS

Nearest CpG islands

None/Target, chr4-CpG: 46/Upstream/47979, chr4-CpG: 109/Downstream/164196

Nearest cancer related gene

AFF1(OG, No orient, 0)

Upstream sequence

TGCATTTCACTTTCTATTCCTTCTCGGAAATGCCAGAAGTACATTTGGTACCAGGATGAGAAATTCCTGTTCCTCCTTGTTTTCACACTTGAGATGTTTG

Downstream sequence

TGGATGGTTATTGGATCCCCCTGAGTCTCTCCAGTTGTGCCTTTGCCAAGATATAGACATTCAACTCTTTTGAATCTTCCCAGACTGCATGTGCTCTCCC