Basic Information
VIS ID
TVIS44019433
Fusion event
HTLV-1-BMPR1B-DT integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
95674142/94752991 (Hg38)
End
95674142/94752991 (Hg38)
Orient
+
Location type
ncRNA_intronic
Fragile sites / regions
FRA4E
Target gene
BMPR1B-DT
Nearest miRNA
hsa-mir-12113/Upstream/7452408; hsa-mir-1243/Downstream/4244396;
Nearest TSS
ENST00000502981/Upstream/77746; ENST00000502683/Downstream/4542;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/300607, chr4-CpG: 137/Downstream/4656
Upstream sequence
TGCAAAAATCTGCTTTTGAGCTAAAAGCACCCATTTCTAGCTAGGAAAACCGGGGGAGAGTAGTAAAAGACAGGGAAAAGATCCTAAAGAAGCTTACAAC
Downstream sequence
TTGGCAAAAGGCATAGGCAAGGTGATTAAGCACTGACCCAGAGAGGGGAGTTTTAAAAGCCACAGACCTCATTGCTTCCCAGGTCTCTGCTATCACCAGC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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