Basic Information
VIS ID
TVIS44019434
Fusion event
HTLV-1-BMPR1B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
95872342/94951191 (Hg38)
End
95872342/94951191 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA4E
Target gene
BMPR1B
miRNAs that regulate target gene
hsa-mir-125b-5p ; hsa-let-7a-5p ; hsa-mir-22-3p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-4705 ; hsa-mir-4668-3p ; hsa-mir-548c-3p
Nearest miRNA
hsa-mir-12113/Upstream/7650608; hsa-mir-1243/Downstream/4046196;
Nearest TSS
ENST00000502981/Upstream/193223; ENST00000502683/Downstream/44605;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/192533, chr4-CpG: 20/Downstream/597114
Upstream sequence
aggaatgcttgtgattattgcatattaattttgtatcctgagacttcactgaagttgcttatcagcttaaggagatttgggctcagatgatggggttttc
Downstream sequence
taaatatacaatcatgtcatctgcaaacagagataaattgccttcctctcttcctatttgaataccctttatttctttctcttgcctgattgccctggcc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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