Basic Information
VIS ID
TVIS44019436
Fusion event
HTLV-1-SLC2A9 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p16.1
Reference genome
GRCh37/hg19
Start
9846411/9844787 (Hg38)
End
9846411/9844787 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA4A
Target gene
SLC2A9
miRNAs that regulate target gene
hsa-mir-5691 ; hsa-mir-6805-3p ; hsa-mir-466 ; hsa-mir-6740-3p ; hsa-mir-4778-3p ; hsa-mir-4643 ; hsa-mir-4789-3p ; hsa-mir-1264 ; hsa-mir-4446-5p ; hsa-mir-3156-3p ; hsa-mir-1260b ; hsa-mir-1260a ; hsa-mir-188-3p ; hsa-mir-1224-3p ; hsa-mir-4307 ; hsa-mir-33a-3p
Nearest miRNA
hsa-mir-378d-1/Upstream/288471; hsa-mir-12113/Downstream/233824;
Nearest TSS
ENST00000502981/Upstream/18187; ENST00000504249/Downstream/42855;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/61451, chr4-CpG: 49/Downstream/174070
Upstream sequence
ctggtgtctacagtgaggaacaatctgctacctttctttctcCAGagataaacctgatataaattcccatcactttacctactagctatgtgaccacatg
Downstream sequence
tatctatggttctcagttttctcatctataaaatgaagataacaatagttcctacttagttttgttttatgcattaaatgagaCTGTGCTTAGCAATGCA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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