Basic Information
VIS ID
TVIS44019446
Fusion event
HTLV-1-FBXL17 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
107714010/108378309 (Hg38)
End
107714010/108378309 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA5F
Target gene
FBXL17
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-186-3p ; hsa-mir-548p ; hsa-mir-548b-3p ; hsa-mir-330-3p
Nearest miRNA
hsa-mir-10397/Upstream/7561744; hsa-mir-103a-1/Downstream/2135520;
Nearest TSS
ENST00000502646/Upstream/10355; ENST00000513676/Downstream/2654;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/705819, chr5-CpG: 220/Downstream/2299
Upstream sequence
TCTCCTCTGCCATAAAAAAAAAAAAATGGGCAAGTATGGTAGCTTTCCCAAAAAACATCCTTTAAATTCTTAAACATCCTCACATTTCTCTCCCAAATTC
Downstream sequence
TACCTGCCTCGTttttgttttttgtttttttgttttgttttgttttgttttTACAGCTATAGTAACTTCCTAGCATAAAAGATGAAGCAAAAGCAATACA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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