Basic Information
VIS ID
TVIS44019469
Fusion event
HTLV-1-FSTL4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
133010158/133674467 (Hg38)
End
133010158/133674467 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA5C
Target gene
FSTL4
miRNAs that regulate target gene
hsa-mir-3691-5p ; hsa-mir-432-3p ; hsa-mir-6508-3p ; hsa-mir-4726-5p ; hsa-mir-4640-5p ; hsa-mir-1193 ; hsa-mir-6849-5p ; hsa-mir-3681-5p ; hsa-mir-6856-5p ; hsa-mir-6758-5p ; hsa-mir-4472 ; hsa-mir-3175 ; hsa-mir-4447 ; hsa-mir-6878-5p ; hsa-mir-5703 ; hsa-mir-4516 ; hsa-mir-4434 ; hsa-mir-3202 ; hsa-mir-4533 ; hsa-mir-7515 ; hsa-mir-194-3p ; hsa-mir-1296-3p ; hsa-mir-7845-5p ; hsa-mir-4475 ; hsa-mir-4662b ; hsa-mir-4426 ; hsa-mir-4647 ; hsa-mir-4446-5p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-4452 ; hsa-mir-183-3p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-623 ; hsa-mir-4742-3p ; hsa-mir-6780b-3p ; hsa-mir-4780 ; hsa-mir-7856-5p ; hsa-mir-4503 ; hsa-mir-6792-5p
Nearest miRNA
hsa-mir-10397/Upstream/246761; hsa-mir-103a-1/Downstream/551290;
Nearest TSS
ENST00000502646/Upstream/61903; ENST00000513561/Downstream/239210;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/61691, chr5-CpG: 36/Downstream/293828
Nearby gene
FSTL4(-61935) ;
Upstream sequence
GGCCTTTAGATAAATGGGGATTGTAGGATCATTTCTAATACTACCAGTAACCATGAGGATATACCCTTCACACAAAGTAACCAAAAGAGAAAAAGGATCT
Downstream sequence
TCATGTACTATAATAAATAGGAAAAGCTAACTTTATTAATTTAGATCCCATTAAGATGAAAAGAAACCTTGAGAAATCCCGTAGAGAACGAGACAGGCAT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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