Basic Information
VIS ID
TVIS44019502
Fusion event
HTLV-1-SGCD integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q33.2
Reference genome
GRCh37/hg19
Start
155641205/156214195 (Hg38)
End
155641205/156214195 (Hg38)
Orient
-
Location type
Intronic
Target gene
SGCD
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-647 ; hsa-mir-1294 ; hsa-mir-4316 ; hsa-mir-6762-3p ; hsa-mir-604 ; hsa-mir-3926 ; hsa-mir-4480 ; hsa-mir-5008-5p ; hsa-mir-6089 ; hsa-mir-4761-5p ; hsa-mir-641 ; hsa-mir-3617-5p ; hsa-mir-10b-3p ; hsa-mir-5680 ; hsa-mir-1305 ; hsa-mir-607 ; hsa-mir-511-5p ; hsa-mir-6830-3p ; hsa-mir-627-3p ; hsa-mir-4698 ; hsa-mir-8063 ; hsa-mir-4307 ; hsa-mir-6839-3p ; hsa-mir-519e-5p ; hsa-mir-515-5p ; hsa-mir-629-5p ; hsa-mir-365b-5p ; hsa-mir-365a-5p ; hsa-mir-8052 ; hsa-mir-3199 ; hsa-mir-5695 ; hsa-mir-519d-5p ; hsa-mir-4506 ; hsa-mir-335-3p ; hsa-mir-4477a ; hsa-mir-6759-3p ; hsa-mir-3152-3p ; hsa-mir-33a-3p ; hsa-mir-409-3p ; hsa-mir-320e
Nearest miRNA
hsa-mir-10397/Upstream/1384655; hsa-mir-103a-1/Downstream/4260207;
Nearest TSS
ENST00000502646/Upstream/343851; ENST00000524347/Downstream/112551;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/484821, chr5-CpG: 45/Downstream/636096
Nearby gene
SGCD(+112562) ;
Upstream sequence
cctagcctgggtaagtagacaggaaaaataaataaaaggcatccaaattggaaagaaaaatgttaaattatctctgcttgcagatatcaggatcttaata
Downstream sequence
cacagaaaaccctcaagacttcacaaaaaactattagatctaataaatgaatttagtaaatttacaggataccaaatcaacctaccaaaatcagtatcat
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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