Basic Information
VIS ID
TVIS44019505
Fusion event
HTLV-1-FBXL7 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
p15.1
Reference genome
GRCh37/hg19
Start
15768803/15768694 (Hg38)
End
15768803/15768694 (Hg38)
Orient
+
Location type
Intronic
Target gene
FBXL7
miRNAs that regulate target gene
hsa-mir-3912-5p ; hsa-mir-527 ; hsa-mir-518a-5p ; hsa-mir-5681b ; hsa-mir-31-3p ; hsa-mir-571 ; hsa-mir-219a-1-3p ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-4461 ; hsa-mir-5579-5p ; hsa-mir-520e ; hsa-mir-520d-3p ; hsa-mir-520c-3p ; hsa-mir-520b ; hsa-mir-520a-3p ; hsa-mir-373-3p ; hsa-mir-372-3p ; hsa-mir-302e ; hsa-mir-302d-3p ; hsa-mir-302c-3p ; hsa-mir-302b-3p ; hsa-mir-302a-3p ; hsa-mir-93-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-106b-5p ; hsa-mir-106a-5p
Nearest miRNA
hsa-mir-10397/Upstream/942682; hsa-mir-103a-1/Downstream/166488;
Nearest TSS
ENST00000502646/Upstream/161346; ENST00000329673/Downstream/159194;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/267880, chr5-CpG: 34/Downstream/159285
Upstream sequence
TTTAGTACAGAACCACCAGTGGAAAGAAAAGGTTATTGAAAAGTTTGAGTGGGGGTGAACTGCCTTCTTCTGGGATGGGGCTGGTCATGATAGTACACAC
Downstream sequence
AGAGCGTGGTCCACTCATGGTGTGGTGTGTTTCTCCACTAGTGCTGGTCCAGCCAGGGCTCCACTCAGCCCTGCCTCCCTGTGCACAGTGGCCACAGTGC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate