Basic Information
VIS ID
TVIS44019518
Fusion event
HTLV-1-STK10 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q35.1
Reference genome
GRCh37/hg19
Start
171614491/172187487 (Hg38)
End
171614491/172187487 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA5G
Target gene
STK10
miRNAs that regulate target gene
hsa-mir-484 ; hsa-mir-1225-3p ; hsa-mir-1233-3p ; hsa-mir-1255a ; hsa-mir-1255b-5p ; hsa-mir-214-3p ; hsa-mir-302c-3p ; hsa-mir-3617-3p ; hsa-mir-3619-5p ; hsa-mir-365a-5p ; hsa-mir-365b-5p ; hsa-mir-3940-3p ; hsa-mir-4291 ; hsa-mir-4519 ; hsa-mir-4652-5p ; hsa-mir-520f-3p ; hsa-mir-6512-3p ; hsa-mir-6720-5p ; hsa-mir-6849-3p ; hsa-mir-761 ; hsa-mir-922
Nearest miRNA
hsa-mir-10397/Upstream/800727; hsa-mir-10523/Downstream/474678;
Nearest TSS
ENST00000502646/Upstream/30762; ENST00000398186/Downstream/899;
Nearest CpG islands
chr5-CpG: 162/Target, None/Upstream, None/Downstream
Nearest cancer related gene
STK10(TSG, No orient, 0)
Upstream sequence
TCTCTGGCTCATCTTCAGATGTGTCCCTAGCTCCCAACCCGTCCAAGCGCAGCCGAGTTTCTCGGTCCACATCGCCTCGATATTCCCACAGCATCTGTGG
Downstream sequence
TCTCTCTTAAAAAAAAAAGTGTGCCCGTATCGCCGTTTTACGGAACGTCCCTGGAAGGTCCCTCGAGTGGCCCTCTCGGATGCTGAGGTCCTGTCAACGC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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