Basic Information
VIS ID
TVIS44019524
Fusion event
HTLV-1-MGAT1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q35.3
Reference genome
GRCh37/hg19
Start
180237725/180810725 (Hg38)
End
180237725/180810725 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA5G
Target gene
MGAT1
miRNAs that regulate target gene
hsa-mir-122-5p ; hsa-mir-1278 ; hsa-mir-143-5p ; hsa-mir-186-3p ; hsa-mir-3135b ; hsa-mir-3194-3p ; hsa-mir-3652 ; hsa-mir-3973 ; hsa-mir-432-5p ; hsa-mir-4430 ; hsa-mir-5004-3p ; hsa-mir-504-3p ; hsa-mir-548av-5p ; hsa-mir-548k ; hsa-mir-5691 ; hsa-mir-5698 ; hsa-mir-6499-3p ; hsa-mir-6805-3p ; hsa-mir-8054
Nearest miRNA
hsa-mir-10397/Upstream/795328; hsa-mir-4638/Downstream/232678;
Nearest TSS
ENST00000502646/Upstream/220; ENST00000508309/Downstream/195;
Nearest CpG islands
chr5-CpG: 110/Target, None/Upstream, None/Downstream
Nearby gene
MGAT1(-588) ;
Upstream sequence
CGCCCAGCGACGGCCTGCTTGACCTGGTTTCTCAAAAAGGGTGACCCCCCCCCTCCGCCCCACGCTGGTCGCGGGTCCTGGCGAGAAGCCTTTCGGAAAG
Downstream sequence
CACCGGGGCCTGTGTGTTCCCGCTTCCTCGGACGCGAGCTCTGTGTAGCCGTGGTGGAGGAAGGTTTTGTTTCGTTCATCGCTGCTGTTTCTCGCTGCCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate