Basic Information
VIS ID
TVIS44019528
Fusion event
HTLV-1-CDH18 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
p14.3
Reference genome
GRCh37/hg19
Start
20007683/20007574 (Hg38)
End
20007683/20007574 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA5E
Target gene
CDH18
miRNAs that regulate target gene
hsa-let-7e-5p
Nearest miRNA
hsa-mir-10397/Upstream/2851582; hsa-mir-103a-1/Downstream/11928528;
Nearest TSS
ENST00000502646/Upstream/19344; ENST00000513573/Downstream/297991;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/2351960, chr5-CpG: 45/Downstream/297879
Upstream sequence
CCAAGAAACTATTACAGTTAAATGTCCATGAAATCTTTGAATACGAAAGGAATTTTTAAGCATGACTCAAAATATAGAAATGATGGATTGCTCATGGaag
Downstream sequence
aaagaaagtgtgaatagtgcagaattagcaagagagagagtagcgggagttgaaatcagagatgtTTATTTAATAGTTTGAAGTGCAGTGTGTGGAAAgt
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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