Basic Information
VIS ID
TVIS44019546
Fusion event
HTLV-1-RAI14 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
34702694/34702589 (Hg38)
End
34702694/34702589 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA5A
Target gene
RAI14
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-122-5p ; hsa-mir-26b-5p ; hsa-mir-21-5p ; hsa-mir-423-3p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-10397/Upstream/2308114; hsa-mir-103a-1/Downstream/1445303;
Nearest TSS
ENST00000502646/Upstream/14400; ENST00000502736/Downstream/13497;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/45364, chr5-CpG: 69/Downstream/136227
Upstream sequence
AAGTGAGCGGGGGAAGAAACAGGTCTCAAATATTTAATCAGGTTAAAAGCAGTGAATGTTCAGTATCCCAGGCTCTGTTACCTTAATCAAGCCCATTATG
Downstream sequence
GACCCCGTTCACATTAGCATCTCACTTCTCTACTACAAACCTGTGCTTTATAAACAATGCTCGGGTTGGCCACTGTTATAATTTTGGACACACTTAAGGA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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