Basic Information
VIS ID
TVIS44019549
Fusion event
HTLV-1-WDR70 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
37433242/37433140 (Hg38)
End
37433242/37433140 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA5A
Target gene
WDR70
miRNAs that regulate target gene
hsa-mir-6844 ; hsa-mir-6873-3p ; hsa-mir-9-5p ; hsa-mir-4778-3p ; hsa-mir-7152-3p ; hsa-mir-1236-3p ; hsa-mir-6515-3p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-660-3p ; hsa-mir-5193
Nearest miRNA
hsa-mir-10397/Upstream/1285152; hsa-mir-103a-1/Downstream/1124362;
Nearest TSS
ENST00000502646/Upstream/53838; ENST00000510699/Downstream/46330;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/53586, chr5-CpG: 51/Downstream/401429
Upstream sequence
CTTGGCGATATTTTAAAATCTCAGAtttttttttgttgttgttgaacagagtctcagtcacctgggctggagtacagtggcacgatcttggctcattgca
Downstream sequence
accctcacctcctaggttcaagcaattcatgtgcctcagcctcccaagtagttagaattacaggtgtgtgctaccacgcctggctaatttttgtattttt
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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