Basic Information
VIS ID
TVIS44019572
Fusion event
HTLV-1-ADAMTS16 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
p15.32
Reference genome
GRCh37/hg19
Start
5183470/5183357 (Hg38)
End
5183470/5183357 (Hg38)
Orient
-
Location type
Intronic
Target gene
ADAMTS16
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-4277/Upstream/3474489; hsa-mir-10397/Downstream/1644496;
Nearest TSS
ENST00000502646/Upstream/7143; ENST00000513709/Downstream/51680;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/42529, chr5-CpG: 18/Downstream/119793
Upstream sequence
TGCTGAGAACAAACGGAGGTGAGCAGGAGGCTGAGAGAGTTGGGAATCCTGAGGTTGGGTGAGTGTTTGAAAAGGGCGTGCATATCGGCAACAGCTGCCC
Downstream sequence
GAGGCTGCCGTGACCGGCAGGTCAGGACCCAGATGCGTGGCGGAGGCTTCCCCAAGGTCAGAGTCAGGACTCTGCTGCCAGGGCTCACGGTGTGGTTGTG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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