Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene53463412535606335368334053567968535698445356000153561801535458315354600053573376
Basic Information
VIS ID
TVIS44019574
Fusion event
HTLV-1-NDUFS4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
52869206/53573376 (Hg38)
End
52869206/53573376 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA5H
Target gene
NDUFS4
miRNAs that regulate target gene
hsa-mir-1-3p
Nearest miRNA
hsa-mir-10397/Upstream/15015815; hsa-mir-103a-1/Downstream/378128;
Nearest TSS
ENST00000502646/Upstream/12701; ENST00000509443/Downstream/72819;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/12336, chr5-CpG: 59/Downstream/736726
Upstream sequence
tccttctttttgaaaattgtagctattttagttcccttccatcatttagaatcagctcttttataactatgaaatcctgctagggttttgattgtattgc
Downstream sequence
attaaatctatagattaatttgggaaaagttgacatttctgctgtgttgaatctttcaatccataaacatggtatgtctctttatttatttatctaatca
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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