Basic Information
VIS ID
TVIS44019589
Fusion event
HTLV-1-RNF180 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q12.3
Reference genome
GRCh37/hg19
Start
63660795/64364968 (Hg38)
End
63660795/64364968 (Hg38)
Orient
+
Location type
Intronic
Target gene
RNF180
Nearest miRNA
hsa-mir-10397/Upstream/4661265; hsa-mir-103a-1/Downstream/7804499;
Nearest TSS
ENST00000502646/Upstream/198806; ENST00000508162/Downstream/141289;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/198689, chr5-CpG: 73/Downstream/140986
Nearest cancer related gene
RNF180(TSG, No orient, 0)
Upstream sequence
atattctctaatggttacttgtatttctgtggagtcagtggtgtaatatcccctttgttgtttctgattgtttacttggatcttctcttttattatttac
Downstream sequence
tagtctagctagtggcctgtcttaattttttcaaaaaaaaaaacagcttttggttttgttgatcttttgaatgctttttgtgtctgtctccttcagttca
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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