Basic Information
VIS ID
TVIS44019595
Fusion event
HTLV-1-ARHGEF28 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
73025066/73729241 (Hg38)
End
73025066/73729241 (Hg38)
Orient
+
Location type
Intronic
Target gene
ARHGEF28
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-19b-3p ; hsa-mir-203a-3p ; hsa-mir-4635 ; hsa-mir-302a-5p ; hsa-mir-7161-3p ; hsa-mir-338-3p ; hsa-mir-7157-5p ; hsa-mir-4310 ; hsa-mir-1226-3p ; hsa-mir-634 ; hsa-mir-6771-3p
Nearest miRNA
hsa-mir-10397/Upstream/850578; hsa-mir-103a-1/Downstream/9110914;
Nearest TSS
ENST00000502646/Upstream/44409; ENST00000510131/Downstream/57250;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/102539, chr5-CpG: 29/Downstream/180244
Upstream sequence
CTGcctggctcagcctcctgacaagctgtgtgatcttaggcaagttatttaagtgctccctgcctcagtttcctcatttgtcaaatgaggattataatag
Downstream sequence
acacctacctcaaaggactgttgtgggattaaactgatcaactgaaagctgttagaactgagattgacaGGTTGGCTAGGTGATGATATGTGTTGCTCTA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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