Basic Information
VIS ID
TVIS44019597
Fusion event
HTLV-1-chr5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
75377529/76081704 (Hg38)
End
75377529/76081704 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC105379041 ; SV2C
miRNAs that regulate target gene
hsa-mir-526a ; hsa-mir-523-5p ; hsa-mir-522-5p ; hsa-mir-520c-5p ; hsa-mir-519c-5p ; hsa-mir-519b-5p ; hsa-mir-519a-5p ; hsa-mir-518f-5p ; hsa-mir-518e-5p ; hsa-mir-518d-5p ; hsa-mir-6502-5p ; hsa-mir-1301-5p ; hsa-mir-517-5p ; hsa-mir-520g-5p ; hsa-mir-3613-3p ; hsa-mir-6856-5p ; hsa-mir-6758-5p
Nearest miRNA
hsa-mir-10397/Upstream/3203041; hsa-mir-103a-1/Downstream/6758451;
Nearest TSS
ENST00000502646/Upstream/364223; ENST00000506257/Downstream/1468;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/364014, chr5-CpG: 30/Downstream/369
Nearby gene
SV2C(+1710) ;
Upstream sequence
TTTCATATTGCCTGACCATCTCATAGCACCATGGTCACAGACTGCAAAGCCTCTCACCGGAACAAGACAGACCAGCAAGGAAGTGTAGGTTCAACAGCAC
Downstream sequence
ATGAGAATCATAACTTTTAGTGCCAGAGTGTCTGAACCAGAGAGGAGGGAAAATGAGAGGCCAAGAGTTGTCTCCATTTTCTTCTCTTCACAGTATCCTG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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