Basic Information
VIS ID
TVIS44019603
Fusion event
HTLV-1-TENT2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
78960601/79664778 (Hg38)
End
78960601/79664778 (Hg38)
Orient
+
Location type
Intronic
Target gene
TENT2
miRNAs that regulate target gene
hsa-mir-374b-5p ; hsa-mir-590-3p ; hsa-mir-375 ; hsa-mir-130b-3p ; hsa-mir-148a-3p ; hsa-mir-19b-3p ; hsa-mir-615-3p ; hsa-let-7e-5p ; hsa-mir-19a-3p ; hsa-mir-130a-3p ; hsa-mir-152-3p ; hsa-mir-301a-3p ; hsa-mir-148b-3p ; hsa-mir-1468-3p ; hsa-mir-454-3p ; hsa-mir-301b-3p ; hsa-mir-548f-5p ; hsa-mir-548g-5p ; hsa-mir-548x-5p ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-548aj-5p ; hsa-mir-4698 ; hsa-mir-548aw ; hsa-mir-139-5p ; hsa-mir-7106-3p ; hsa-mir-2116-3p ; hsa-mir-885-5p
Nearest miRNA
hsa-mir-10397/Upstream/6786115; hsa-mir-103a-1/Downstream/3175377;
Nearest TSS
ENST00000502646/Upstream/7897; ENST00000510721/Downstream/3943;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/51910, chr5-CpG: 34/Downstream/24823
Upstream sequence
ACCTGAATTTTGAAAACGTAGAAAAATTAATTTGGAAATAATACATGAAAATTTTCAGGAGGTAACCACACTGTATTGTATAAATGTGCAATAATAATGA
Downstream sequence
TATGTGGCATATACTAAACAGTTAATAaatccttacaaccatctgagtatttttcctttccttgtattataaatgatgaagctgaggaacgctaagtaac
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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