Basic Information
VIS ID
TVIS44019608
Fusion event
HTLV-1-EDIL3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q14.3
Reference genome
GRCh37/hg19
Start
83616299/84320481 (Hg38)
End
83616299/84320481 (Hg38)
Orient
+
Location type
Intronic
Target gene
EDIL3
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-377-3p ; hsa-mir-676-5p ; hsa-mir-3691-3p ; hsa-mir-1228-3p ; hsa-mir-4698 ; hsa-mir-8063 ; hsa-mir-1264 ; hsa-mir-4668-5p ; hsa-mir-4328 ; hsa-mir-548t-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-7154-5p ; hsa-mir-8060
Nearest miRNA
hsa-mir-10397/Upstream/1480257; hsa-mir-103a-1/Downstream/2794398;
Nearest TSS
ENST00000502646/Upstream/139239; ENST00000507060/Downstream/63905;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/597942, chr5-CpG: 25/Downstream/61838
Upstream sequence
ccttaaatccaattaaacagtatctacattttaacggcttcccaggagccctgggaagctgtatattcgctcaagtttgagaagtaTGGCAGCCAGCTCC
Downstream sequence
AGCCCATCCAAGGAAAGGGACATTAAATACAATCTGGTCAGCAGGCCTCATTGATCAAACATGTCAGTTAGAGACCTGCACACTTAATGAAGATCTCATA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate